The Our Lady of Wisdom Cathedral, also known as the Cathedral Limbe Our Lady of Wisdom or simply the Cathedral of Blantyre, stands as a significant place of worship within the second largest city of Malawi. This cathedral adheres to the Roman rite and acts as the central hub for the Archdiocese of Blantyre, an entity established in 1959 by Pope John XXIII through his bull Cum fides christiana.

Under the leadership of Archbishop Thomas Luke Msusa, the cathedral offers masses in both English and Chichewa, catering to a diverse congregation. It remains a vital spiritual landmark for the Catholic community in Blantyre.